MODULES MUST BE ORDERED AND INSTALLED IN IDENTICAL GROUPS OF FOUR for Quad Channel mode.
Per Intel, mixing module types (x4 and x8) is NOT allowed within a bank group or channel.
JEDEC spec "KSM" Server Premier Registered DIMMs will operate at 4800MT/s installed in 1DPC (1 DIMM per Channel) in Quad Channel configuration using Intel Xeon W9, W7 and W5 series processors. Due to processor/chipset limitations, 4800MT/s DDR5 RDIMMs installed in 2DPC (2 DIMMs per Channel) in Quad Channel configuration are limited to operate at and will safely clock down to 4400MT/s. Xeon W3 series and W5-3423 / W5-3433 models limit memory speed to 4400MT/s, regardless of DIMM configuration.
Mixing ranks with 16Gbit-based modules is permitted within a channel if they are the same module type (2Rx4 + 1Rx4 / 2Rx8 + 1Rx8). 2R (Dual Rank) DIMMs must always be populated in the first memory bank if combined with 1R (Single Rank) DIMMs installed in the second memory bank.
All 5600MT/s and 4800MT/s memory will safely clock down to slower speeds when forced by the chipset/processor.
Refer to motherboard manual and QVL for supported memory configurations and speeds.